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The BEYOND Study

See all Clinical Trials


Are you living with IgA nephropathy?

The BEYOND study is a phase 3, randomized, double-blind, placebo-controlled study of zigakibart
(BION-1301) in adults with IgA nephropathy (IgAN). The BEYOND study is a clinical trial that will
test an investigational drug named zigakibart which is being developed for the treatment of
IgAN. The goal of the study is to see if zigakibart has an effect on how well your kidneys work by
measuring the level of protein in your urine (proteinuria) and how well your kidneys are filtering
blood (estimated glomerular filtration rate also known as eGFR). The study is also planning to see
if zigakibart is safe and well tolerated in patients with IgAN.

About 292 adults will take part in this study worldwide. This study will be conducted at about
200 study centers worldwide. Participation in the study involves up to 57 visits over the course of
31 months (about 2 and a half years). Participants who qualify may be reimbursed for their time
and travel costs like mileage and lodging for taking part in the clinical study.

Who Can Join?

You may qualify to participate in this study if you are:

  • Age 18 and older
  • Have been diagnosed with IgA nephropathy by kidney biospy.
  • Have urine containing total protein levels of ≥ 1.0 g/day and a urine protein creatinine ratio (UPCR) of ≥ 0.7 g/g
  • eGFR of >/= 30 mL/min/1.73 m2
  • Willingness to use contraception

Currently Open

Learn more by visiting: https://clinicaltrials.gov/study/NCT05852938

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(848) 298-4618

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PO Box 1322 Wall, NJ 07727

© 2023 All Rights Reserved.

May 14, Sunday: Mother’s Day & IgA Nephropathy Awareness Day

The IgAN Foundation was sparked by a mother’s love and has grown into a community sharing crucial resources and working toward a cure. This day kicks off a week of celebrating the IGA Nephropathy family all week!

May 15, Monday: Mindfulness

IgA Nephropathy can be challenging and mindfulness is an important part of caring for yourself. Take a moment today and implement a mindfulness practice, meditate, or take a few moments in reflection to check in with yourself.

May 16, Tuesday: Share Your Story

On this day, the Foundation will share the video with Warrior stories compiled (submit yours here if you haven’t yet). We encourage you to also share your own photos and videos from moments along your journey!

May 17, Wednesday: Wellness

What are you doing to feel well today? IgA Nephropathy can sometimes make life feel uncontrollable, but there are some things we can control, for example:

  • Enjoyable movement (a stretch, a walk, dancing to a favorite song)
  • Eating food that’s right for us individually
  • Checking in with ourselves
  • Meditating

May 18, Thursday: Thank those who care

Between care teams, care partners, and medical providers, a lot goes into the care that sustains us as we live with IgA Nephropathy. Take this opportunity to express your appreciation to them!

May 19, Saturday: Rally cry

When the IgA Nephropathy Foundation was created, there were no resources to treat IgA Nephropathy. Now, there are 2 approved FDA treatments and many clinical trials in the works. Our community is strong and full of hope— here’s to even more progress in the future!

May 20, Saturday: Celebration! 

We’ll be hosting an in-person celebration (details to come). We’ll miss you if you can’t make it, but please take the time to celebrate however works for you — wearing your IgAN Foundation sunglasses, spending time with loved ones, etc. — just be sure to share a photo and tag us!

References

  • Hall, Y.N., Fuentes, E.F., Chertow, G.M. et al. Race/ethnicity and disease severity in IgA nephropathy. BMC Nephrol 5, 10 (2004). https://doi.org/10.1186/1471-2369-5-10
  • Kiryluk K, Li Y, Sanna-Cherchi S, Rohanizadegan M, Suzuki H, et al. (2012) Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis. PLoS Genet 8(6): e1002765. doi:10.1371/journal.pgen.1002765