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Resources

IGA NEPHROPATHY GUIDE

IgA Nephropathy – What You Need to Know Your Guide to Managing and Living Well with the Condition If you or a loved one has been diagnosed with IgA Nephropathy, you may feel overwhelmed and flooded with questions about what the diagnosis might mean for you now and in the future. It’s normal to feel […]

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Igan Basics

There is a lot of technical language around IgAN and it can seem confusing and overwhelming when receiving a diagnosis for yourself or a loved one. You may have many questions regarding what it is, how it effects your body, how you got it, and the treatment course that may be available to you. The […]

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National Kidney Foundation’s and IgA Nephropathy Foundation’s Externally-Led Patient Focused Drug Development (EL-PFDD) Meeting on IgA Nephropathy

The NKF and IGANF conducted an EL-PFDD meeting on IgAN to inform the FDA on the patient perspective on living with this disease. Understanding the patient perspective will help the FDA when it decides whether to approve potential medicines for IgAN. On August 19, 2019, the National Kidney Foundation and the IGA Nephropathy Foundation of […]

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Ten Years Follow-up of STOP-IgAN Trial

Abstract The randomized, controlled STOP-IgAN trial in patients with IgA nephropathy (IgAN) and substantial proteinuria showed no benefit of immunosuppression added on top of supportive care on renal function over three years. As a follow-up we evaluated renal outcomes in patients over a follow-up of up to ten years in terms of serum creatinine, proteinuria, […]

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Proteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy

Abstract IgA nephropathy (IgAN) is an important cause of ESKD for which there are no approved therapies. A challenge for evaluating treatments for IgAN is the usual long time course for progression to ESKD. The aim of this Kidney Health Initiative projectwas toidentify surrogate end points that could serve as reliable predictors of a treatment’s […]

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2020 1st Quarter Report – UAB Findings in IgA Nephropathy

Diagnosis of IgA nephropathy The diagnostic feature of immunoglobulin A (IgA) nephropathy (IgAN) is the substantial accumulation of IgA in the filtering structures (glomeruli) of the kidneys. When IgAN was first described in 1968, most patients also had another antibody, IgG, in the glomeruli. The diagnosis of IgAN does not however require IgG to be […]

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IgA February

Volume 03 | February 29, 2020 IgA Nephropathy Foundation News KidneyX Update On Thursday, February 6, the IgAN Foundation attended the KidneyX Congressional Briefing. KidneyX is a public-private partnership between the US Department of Health and Human Services and the American Society of Nephrology to accelerate innovation in the prevention, diagnosis, and treatment of kidney diseases. […]

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Pivotal role found for IgG autoantibodies in IgA nephropathy

The most common form of the kidney disease called glomerulonephritis is IgA nephropathy.  Now a study published in the Journal of the American Society of Nephrology by researchers at the University of Alabama at Birmingham largely validates the hypothesis that a second immunoglobulin, IgG, is a crucial part of the pathogenic immunodeposits in glomeruli of patients with IgA nephropathy. […]

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