Published Research Articles

October 2018 – IgA Nephropathy Research Team at UAB: 2018 Progress Report

October 2018 – Progress Report for IGA Nephropathy Foundation of America

April 12, 2016 – The Origin and Activities of igA1- Containing immune Complexes in igA Nephropathy

March 21, 2016 – Markers for the progression of IgA nephropathy

February 11, 2016 – IgA nephropathy

February 4, 2016 – Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy

2016 – Heterogeneity of Aberrant O-Glycosylation of IgA1 in IgA Nephropathy

May 1, 2015 –New Insights into the Pathogenesis of IgA Nephropathy

2015 – IgA Nephropathy and Related Diseases

2015 – Current Understanding of the Role of Complement in IgA Nephropathy

October 12, 2014 –Discovery of new risk loci for IgA Nephropathy implicates genes involved in immunity against intestinal pathogens. Kiryluk, K., Li, Y., Scolari, F., Sanna-Cherchi, S., Choi, M., Verbitsky, M., …… Gharavi, G. A. (2014). Discovery of new risk loci for iga nephropathy implicates genes involved in immunity against intestinal pathogens. Nature Genetics, 46(11), 1187-1199

October 3, 2014 –N-Acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy

July 23, 2014 – Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease.Reily, C., Ueda, H., Huang, Z.,Mestecky, J., Julian, A. B., Willey, D. C., & Novak, J. (2014). Cellular signaling and production of galactose-deficient iga1 in iga nephropathy, an autoimmune disease. Journal of Immunology Research, 1-10

July 1, 2014 – The combined role of galactose-deficient IgA1and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy. Schmitt R, Ståhl AL, Olin AI, Kristoffersson AC, Rebetz J, Novak J, Lindahl G, Karpman D.J Immunol. 2014 Jul 1;193(1):317-26. doi: 10.4049/jimmunol.1302249. Epub 2014 May 21.

June 2014 – The genetics and immunobiology of IgA nephropathy. Kiryluk K, Novak J.J Clin Invest. 2014 Jun;124(6):2325-32. doi: 10.1172/JCI74475. Epub 2014 Jun 2. Review.

June 2014 – Enzymatic Sialylation of IgA1 O-Glycans: Implications for Studies of IgA Nephropathy. Takahashi K, Raska M, Stuchlova Horynova M, Hall SD, Poulsen K, Kilian M, Hiki Y, Yuzawa Y, Moldoveanu Z, Julian BA, Renfrow MB, Novak J. PLoS One. 2014 Jun 11;9(2):e99026. doi: 10.1371/journal.pone.0099026. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e113577.

February, 2014 – Cytokines Alter IgA1 O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes*. Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J. J Biol Chem. 2014 Feb 21;289(8):5330-9. doi: 10.1074/jbc.M113.512277. Epub 2014 Jan 7.

2014 – Immune profile of IgA-dominant diffuse proliferative glomerulonephritis. Wallace E, Maillard N, Ueda H, Hall S, Fatima H, Novak J, Julian BA.Clin Kidney J. 2014 Oct;7(5):479-83. doi: 10.1093/ckj/sfu090.

2014 – Development of animal models of human IgA nephropathy. Suzuki H, Suzuki Y, Novak J, Tomino Y. Drug Discov Today Dis Models. 2014 Spring;11:5-11.

September 23, 2011 –JASN The Pathophysiology of IgA Nephropathy. Hitoshi, S., Kiryluk, K., Novak, J., Moldoveanu, Z., Herr B. A., Renfrow, B. M., …. Julian, A. B. (2011). The pathophysiology of iga nephropathy. Journal of the American Society of Nephrology, 22, 1795-1803.

September 8, 2011 – JASN Current Therapy for IgA Nephropathy. Floege, J., & Eitner F. (2011). Current therapy for iga nephropathy. Journal of the American Society of Nephrology, 22, 1785-1794
September 1, 2011 – IgA Nephropathy and Anti-B-Cell Therapy PowerPoint. Dr Adrian Liew

June 10, 2010 – UAB Search for IgA Nephropathy Screening Tool Intensifies. (2010). UAB search for iga nephropathy screening tool intensifies. UAB Synopsis, 29(26).

Tufts Leadership Team – Dr. Plaut

Tufts Success Stories – Using Enzymes to Reverse Kidney Disease