Published Research Articles

  • 2023 IgA Nephropathy: Pleiotropic impact of Epstein-Barr virus infection on immunopathogenesis and racial incidence of the disease PMID: 36865536 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+36865536 URL: https://pubmed.ncbi.nlm.nih.gov/36865536/ Mestecky, J., Julian, B.A., Raska, M. IgA nephropathy: Pleiotropic impact of Epstein-Barr virus infection on immunopathogenesis and racial incidence of the disease. Front. Immunol. 14, 1085922. doi: 10.3389/fimmu.2023.1085922. 
  • 2023 Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy PMID: 37337107 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+37337107 URL: https://pubmed.ncbi.nlm.nih.gov/37337107/ Kiryluk, K., Sanchez-Rodriguez, E., Zhou, X.-J., Zanoni, F., Liu, L., Mladkova, N., Khan, A., Marasa, M., Zhang, J.Y., Balderes, O., Sanna-Cherchi, S., Bomback, A.S., Canetta, P.A., Appel, G.B., Radhakrishnan, J., Trimarchi, H., Sprangers, B., Cattran, D.C., Reich, H., Pei, Y., Ravani, P., Galesic, K., Maixnerova, D., Tesar, V., Stengel, B., Metzger, M., Canaud, G., Maillard, N., Berthoux, F., Berthelot, L., Pillebout, E., Monteiro, R., Nelson, R., Wyatt, R.J., Smoyer, W., Mahan, J., Samhar, A.A., Hidalgo, G., Quiroga, A., Weng, P., Sreedharan, R., Selewski, D., Davis, K., Kallash, M., Vasylyeva, T.L., Rheault, M., Chishti, A., Ranch, D., Wenderfer, S.E., Samsonov, D., Claes, D.J., Oleh, A., Goumenos, D., Stangou, M., Nagy, J., Kovacs, T., Fiaccadori, E., Amoroso, A., Barlassina, C., Cusi, D., Del Vecchio, L., Battaglia, G.G., Bodria, M., Boer, E., Bono, L., Boscutti, G., Caridi, G., Lugani, F., Ghiggeri, G.M., Coppo, R., Peruzzi, L., Esposito, V., Esposito, C., Feriozzi, S., Polci, R., Frasca, G., Galliani, M.,Garozzo, M., Mitrotti, A., Gesualdo, L., Granata, S., Zaza, G., Londrino, F., Magistroni, R., Pisani, I., Magnano, A., Marcantoni, C., Messa, P., Mignani, R., Pani, A., Ponticelli, C., Roccatello, D., Salvadori, M., Salvi, E., Santoro, E., Gembillo, G., Savoldi, S., Spotti, D., Zamboli, P., Izzi, C., Alberici, F., Delbarba, E., Florczak, M., Krata, N., Mucha, K., Pączek, L., Niemczyk, S., Moszczuk, B., Pańczyk-Tomaszewska, M., Mizerska-Wasiak, M., Perkowska-Ptasińska, A., Bączkowska, T., Durlik, M., Pawlaczyk, K., Sikora, P., Zaniew, M., Kaminska, D., Krajewska, M., Kuzmiuk-Glembin, I., Heleniak, Z., Bullo-Piontecka, B., Liberek, T., Dębska-Slizien, A., Hryszko, T., Materna-Kiryluk, A., Miklaszewska, M., Szczepańska, M., Dyga, K., Machura, E., Siniewicz-Luzeńczyk, K., Pawlak-Bratkowska, M., Tkaczyk, M., Runowski, D., Kwella, N., Drożdż, D., Habura, I., Kronenberg, F., Prikhodina, L., van Heel, D., Fontaine, B., Cotsapas, C., Wijmenga, C., Franke, A., Annese, V., Gregersen, P.K., Parameswaran, S., Weirauch, M., Kottyan, L., Harley, J.B., Suzuki, H., Narita, I., Goto, S., Lee, H., Kim, D.K., Kim, Y.S., Park, J.H., Cho, B.L., Choi, M., Van Wijk, A. Huerta, A., Ars, E., Ballarin, J., Lundberg, S., Vogt, B., Mani, L.Y., Caliskan, Y., Barratt, J., Abeygunaratne, T.,. Kalra, P.A., Gale, D.P., Panzer, U., Rauen, T., Floege, J., Schlosser, P., Ekici, A.B., Eckardt, K.U., Chen, N., Xie, J., Lifton, R.P., Loos, R.J.F., Kenny, E.E., Ionita-Laza, I., Köttgen, A., Julian, B.A., Novak, J., Scolari, F., Zhang, H., Gharavi, A.G. Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nat. Genet. 55(7), 1091-1105. doi: 10.1038/s41588-023-01422-x
  • 2023 Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy PMID: 37747686  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+37747686+ URL: https://pubmed.ncbi.nlm.nih.gov/37747686/ Rajasekaran, A., Green, T.J., Renfrow, M.B., Julian, B.A., Novak, J., Rizk, D.V. Current understanding of complement proteins as therapeutic targets for the treatment of immunoglobulin A nephropathy. Invited review. Drugs. (IF2022 11.4) 83, 1475-1499. doi: 10.1007/s40265-023-01940-2 
  • 2022 IgA vasculitis with nephritis: update of pathogenesis with clinical implications PMID: 33818625  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+33818625+ URL: https://pubmed.ncbi.nlm.nih.gov/33818625/ Hastings, M.C.,* Rizk, D.V.,* Kiryluk, K., Nelson, R., Zahr, R.S., Novak, J., Wyatt, R.J. IgA vasculitis with nephritis: Update of pathogenesis with clinical implications. (* co-first authors) Pediatr. Nephrol. 37(4),719-733. PMCID: PMC8490493 DOI: 10.1007/s00467-021-04950-y
  • 2022 Biologically Active Circulatory Immune Complexes in IgA Nephropathy Contain Polymeric IgA1, with Galactose-Deficient and Minimally Sialylated O-Glycans, IgG, and Complement C3b and iC3b URL: https://journals.lww.com/jasn/citation/2022/11001/biologically_active_circulatory_immune_complexes.2769.aspx Hall, S., Coffee, S., Huang, Z.Q., Maillard, N., Moldoveanu, Z., Hargett, A.A., Rizk, D., Julian, B.A., Renfrow, M.B., Novak, J. Biologically Active Circulatory Immune Complexes in IgA Nephropathy Contain Polymeric IgA1, with Galactose-Deficient and Minimally Sialylated O-Glycans, IgG, and Complement C3b and iC3b. J. Am. Soc. Nephrol. 33, 780
  • 2022 Cell-Surface Glycoprofiling of IgA1-Secreting Cells from Patients with IgA Nephropathy Reveals Subpopulations with Differential Cytokine Responses and Capacity to Produce Galactose-Deficient IgA1 URL: https://journals.lww.com/jasn/citation/2022/11001/cell_surface_glycoprofiling_of_iga1_secreting.2773.aspx Reily, C., Nakazawa, S., Julian, B.A., Novak, J. Cell-Surface Glycoprofiling of IgA1-Secreting Cells from Patients with IgA Nephropathy Reveals Subpopulations with Differential Cytokine Responses and Capacity to Produce Galactose-Deficient IgA1. J. Am. Soc. Nephrol. 33, 781
  • 2022 High-Resolution Imaging Approaches to Assess Colocalization of Immunoglobulin-Component Chains in Glomerular Immunodeposits in IgA Nephropathy URL: https://journals.lww.com/jasn/citation/2022/11001/high_resolution_imaging_approaches_to_assess.2772.aspx Novak, L., Hall, S., Rizk, D., Moldoveanu, Z., Julian, B.A., Haas, M., Novak, J.  High-Resolution Imaging Approaches to Assess Colocalization of Immunoglobulin-Component Chains in Glomerular Immunodeposits in IgA Nephropathy. J. Am. Soc. Nephrol. 33, 781
  • 2022 Inhibition of Platelet-Derived Growth Factor-Induced Signaling and Filopodia Formation in Cultured Human Mesangial Cells by Sheng Ping, a Chinese Herbal Medicine URL: https://journals.lww.com/jasn/citation/2022/11001/inhibition_of_platelet_derived_growth.2770.aspx Huang, Z.Q., Novak, L., Zhang, X.W., Hall, S., Wang, L., Chen, Y., Julian, B.A., Novak, J. Inhibition of Platelet-Derived Growth Factor-Induced Signaling and Filopodia Formation in Cultured Human Mesangial Cells by Sheng Ping, a Chinese Herbal Medicine. J. Am. Soc. Nephrol. 33, 780
  • 2022 LIF/JAK2/STAT1 Signaling Enhances Production of Galactose-Deficient IgA1 by IgA1-Producing Cell Lines Derived from Tonsils of Patients with IgA Nephropathy URL: https://journals.lww.com/jasn/citation/2022/11001/lif_jak2_stat1_signaling_enhances_production_of.2766.aspx Yamada, K., Huang, Z.Q., Reily, C., Suzuki, H., Novak, J., Suzuki, Y. LIF/JAK2/STAT1 Signaling Enhances Production of Galactose-Deficient IgA1 by IgA1-Producing Cell Lines Derived from Tonsils of Patients with IgA Nephropathy. J. Am. Soc. Nephrol. 33, 779
  • 2022 Serum IgA1-IgG-Containing Immune Complexes from Patients with IgA Nephropathy Activate Cultured Human Mesangial Cells and Associate with Cellular Integrin β1 URL: https://journals.lww.com/jasn/citation/2022/11001/serum_iga1_igg_containing_immune_complexes_from.2771.aspx Huang, Z.Q., Zhang, X.W., Hall, S., Wang, L., Chen, Y., Rizk, D., Julian, B.A., Novak, J. Serum IgA1-IgG-Containing Immune Complexes from Patients with IgA Nephropathy Activate Cultured Human Mesangial Cells and Associate with Cellular Integrin β1. J. Am. Soc. Nephrol. 33, 781
  • 2021 Quantitative assessment of successive carbohydrate additions to the clustered O-glycosylation sites of IgA1 by glycosyltransferases PMID: 33295603  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+33295603+ URL: https://pubmed.ncbi.nlm.nih.gov/33295603/ Stewart, T.S., Takahashi, K., Xu, N., Amol, P., Raska, M., Renfrow, M.B.,* Novak, J.* (*co-corresponding co-senior authors). Quantitative assessment of successive carbohydrate additions to the clustered O-glycosylation sites of IgA1 by glycosyltransferases. Glycobiology. 31(5), 540-556. PMCID: PMC8176776 DOI: 10.1093/glycob/cwaa111
  • 2021 Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment PMID: 34640530  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+34640530+ URL: https://pubmed.ncbi.nlm.nih.gov/34640530/ Knoppova, B., Reily, C., King, R.G., Julian, B.A., Novak, J.,* Green, T.J.* (* co-corresponding authors) Pathogenesis of IgA nephropathy: Current understanding and implications for development of disease-specific treatment. J. Clin. Med., 10, 4501. PMCID: PMC8509647 
  • 2021 Mesangioproliferative Kidney Diseases and Platelet-Derived Growth Factor-Mediated AXL Phosphorylation PMID: 34939009  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+34939009+ URL: https://pubmed.ncbi.nlm.nih.gov/34939009/ Bian, Q., Anderson, J., Zhang, X.W., Huang, Z.Q., Ebefors, K., Nyström, J., Hall, S., Novak, L., Julian, B.A., Willey, C.D., Novak, J. Mesangioproliferative kidney diseases and platelet-derived growth factor-mediated AXL phosphorylation. Kidney Med. 3(6), 1003-1013. PMCID: PMC8664734 DOI: https://doi.org/10.1016/j.xkme.2021.06.007 
  • 2021 Immunoglobulin A Glycosylation and Its Role in Disease PMID: 34687019  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+34687019+ URL: https://pubmed.ncbi.nlm.nih.gov/34687019/ Hansen, A., Reily, C., Novak, J.,* Renfrow, M.B.* (*co-corresponding co-senior authors) Immunoglobulin A glycosylation and its role in disease. In: Antibody Glycosylation. Pezer, M., Editor. Antibody Glycosylation. Exp. Suppl., 112, 433-477. https://doi.org/10.1007/978-3-030-76912-3_14.
  • 2021 IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment PMID: 34768371  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+34768371+ URL: https://pubmed.ncbi.nlm.nih.gov/34768371/ Lai, L., Liu, S., Azrad, M., Hall, S., Hao, C.M., Novak, J., Julian, B.A., Novak, L. IgA vasculitis with nephritis in adults: Histological and clinical assessment. J. Clin. Med. 10, 4851. PMID: 34768371 PMCID: PMC8584405 https://doi.org/10.3390/jcm10214851.
  • 2021 IgA Nephropathy: An Interesting Autoimmune Kidney Disease PMID: 33309134 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+33309134 URL: https://pubmed.ncbi.nlm.nih.gov/33309134/ Rajasekaran, A., Julian, B.A., Rizk, D.V.. IgA nephropathy: An interesting autoimmune kidney disease. Am. J. Med. Sci. 361(2),176-194. doi: 10.1016/j.amjms.2020.10.003. Epub 2020 Oct 8. PMCID: PMC8577278.
  • 2021 IgA glycosylation and immune complex formation in IgAN PMID: 34570260 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+34570260 URL: https://pubmed.ncbi.nlm.nih.gov/34570260/ Suzuki, H.,* Novak, J.* IgA glycosylation and immune complex formation in IgAN. (* co-corresponding authors) Invited review. Semin. Immunopathol. 43(5), 669-678. https://doi.org/10.1007/s00281-021-00883-8
  • 2021 Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy PMID: 33508637 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+33508637 URL: https://pubmed.ncbi.nlm.nih.gov/33508637/ Moldoveanu, Z.,* Suzuki, H.,* Reily, C.,* Satake, K., Novak, L., Xu, N., Huang, Z.Q., Knoppova, B., Khan, A., Hall, S., Yanagawa, H., Brown, R., Winstead, C.J., O’Quinn, D.B., Weinmann, A., Gharavi, A., Kiryluk, K., Julian, B.A., Weaver, C.T., Suzuki, Y., Novak, J. Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy. [*These authors contributed equally] J. Autoimm. 118, 102593. doi: 10.1016/j.jaut.2021.102593. PMCID: PMC7997636
  • 2021 25 years since IgA1 glycosylation changes were first described – what will the next 25 years bring? Kidney  URL: https://karger.com/kdd/article/7/Suppl.%201/1/824516/Proceedings-of-16th-International-Symposium-on-IgA Novak, J. 25 years since IgA1 glycosylation changes were first described – what will the next 25 years bring? Kidney Dis. 7, Suppl. 1, 34-35. DOI: 10.1159/isbn.978-3-318-07031-6
  • 2021 Differential cell cycle and kinase activation in IgA1-producing cells from IgAN patients and healthy controls mediated by cytokine stimulation URL: https://journals.lww.com/jasn/citation/2021/10001/differential_cell_cycle_and_kinase_activation_in.1635.aspx Reily, C., Rizk, D.V., Novak, J. Differential cell cycle and kinase activation in IgA1-producing cells from IgAN patients and healthy controls mediated by cytokine stimulation. J. Am. Soc. Nephrol. 32, 456
  • 2021 Immune complexes in the peripheral blood of patients with IgA nephropathy contain polymeric galactose-deficient IgA1 associated with IgG and complement C3 URL: https://journals.lww.com/jasn/citation/2021/10001/immune_complexes_in_the_peripheral_blood_of.1638.aspx Hall, S., Coffee, S., Maillard, N., Moldoveanu, Z., Craine, E.P., Hargett, A.A., Rizk, D.V., Julian, B.A., Renfrow, M.B., Novak, J. Immune complexes in the peripheral blood of patients with IgA nephropathy contain polymeric galactose-deficient IgA1 associated with IgG and complement C3. J. Am. Soc. Nephrol. 32, 457
  • 2021 Mesangial-cell activation by circulating immune complexes consisting of galactose-deficient IgA1 and IgG autoantibodies from patients with IgA nephropathy URL: https://journals.lww.com/jasn/citation/2021/10001/mesangial_cell_activation_by_circulating_immune.1594.aspx Huang, Z.Q., Zhang, X., Hall, S., Wang, L., Chen, Y., Julian, B.A., Novak, J. Mesangial-cell activation by circulating immune complexes consisting of galactose-deficient IgA1 and IgG autoantibodies from patients with IgA nephropathy. J. Am. Soc. Nephrol. 32, 445
  • 2021 Structural characterization of autoreactive IgG antibodies in the context of IgA nephropathy URL: https://journals.lww.com/jasn/citation/2021/10001/structural_characterization_of_autoreactive_igg.1640.aspx Lingo, J., Knoppova, B., Hall, S., Novak, J., Green, T.J. Structural characterization of autoreactive IgG antibodies in the context of IgA nephropathy. J. Am. Soc. Nephrol. 32, 458
  • 2021 Aberrant O-glycosylation of IgA1 in IgA nephropathy: Single-cell transcriptome analysis identified a subset of IgA1-producing cells with altered expression of C1GALT1 and MAPK ? Reily, C., Crossman, D.K., Julian, B.A., Novak, J. Aberrant O-glycosylation of IgA1 in IgA nephropathy: Single-cell transcriptome analysis identified a subset of IgA1-producing cells with altered expression of C1GALT1 and MAPK. Glycobiology. 31 (12), 1714
  • 2021 Aberrantly O-glycosylated IgA1 and its pathogenic potential in IgA nephropathy: Assessment of biological activities of IgA1-containing immune complexes ? Huang, Z.Q., Hall, S., Anderson, J.C., Willey, C.D., Julian, B.A., Novak, J. Aberrantly O-glycosylated IgA1 and its pathogenic potential in IgA nephropathy: Assessment of biological activities of IgA1-containing immune complexes. Glycobiology. 31 (12), 1712
  • 2021 Characterization of different molecular forms of aberrantly glycosylated IgA1 in the circulation of patients with IgA nephropathy ? Hall, S., Coffee, S., Maillard, N., Craine, E., Hargett, A.A., Moore, B., Rizk, D.V., Julian, B.A., Moldoveanu, Z., Renfrow, M.B., Novak, J. Characterization of different molecular forms of aberrantly glycosylated IgA1 in the circulation of patients with IgA nephropathy. Kidney Dis. 7, Suppl. 1, 63
  • 2021 Differential pathway activation in Ig-producing cells from IgAN patients and healthy controls mediated by cytokine stimulation ? Reily, C., Crossman, D., Julian, B.A., Novak, J. Differential pathway activation in Ig-producing cells from IgAN patients and healthy controls mediated by cytokine stimulation. Kidney Dis. 7, Suppl. 1, 70
  • 2021 Experimental evidence of the pathogenic potential of aberrantly O-glycosylated IgA1, the main autoantigen in IgA nephropathy ? Moldoveanu, Z., Suzuki, H., Reily, C., Satake, K., Novak, L., Xu, N., Huang, Z.Q., Knoppova, B., Khan, A., Hall, S., Yanagawa, H., Brown, R., Winstead, C.J., O’Quinn, D.B., Weinmann, A., Gharavi, A., Kiryluk, K., Julian, B.A., Weaver, C.T., Suzuki, Y., Novak, J. Experimental evidence of the pathogenic potential of aberrantly O-glycosylated IgA1, the main autoantigen in IgA nephropathy. . Glycobiology. 31 (12), 1710
  • 2020 Leukemia Inhibitory Factor Signaling Enhances Production of Galactose-Deficient IgA1 in IgA Nephropathy PMID: 32523959 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+32523959 URL: https://pubmed.ncbi.nlm.nih.gov/32523959/ Yamada, K.,# Huang, Z.-Q.,# Raska, M., Reily, C.R., Aderson, J., Suzuki, H., Kiryluk, K., Gharavi, A.G., Julian, B.A., Willey, C.D.,* Novak, J.* LIF signaling enhances production of galactose-deficient IgA1 in IgA nephropathy. (#co-first authors, *co-senior, co-corresponding authors) Kidney Dis. 6(3), 168-180. PMCID: PMC7265702 doi:10.1159/000505748 [awarded Best Research Paper accepted in 2019]
  • 2020 1st Quarter Report – UAB Findings in IgA Nephropathy
  • 2020 Antibody sequencing analysis after flu vaccine response in IgA nephropathy patients reveal enhanced IgA VH lineage diversity URL: https://journals.lww.com/jasn/citation/2020/10001/antibody_sequencing_analysis_after_flu_vaccine.1998.aspx Reily, C., Knoppova, B., Fucile, C., Rosenberg, A., Rizk, D.V., Julian, B.A., Novak, J., King, R.G. Antibody sequencing analysis after flu vaccine response in IgA nephropathy patients reveal enhanced IgA VH lineage diversity. J. Am. Soc. Nephrol. 31, 561
  • 2020 Can the crosstalk between PDGF receptor and Axl in mesangial cells represent a possible therapeutic target in IgA nephropathy?  URL: https://journals.lww.com/jasn/citation/2020/10001/can_the_cross_talk_between_pdgf_receptor_and_axl.2007.aspx Bian, Q., Huang, Z.Q., Anderson, J.C., Zhang, X.W., Ebefors, K., Nyström, J., Hall, S., Novak, L., Julian, B.A., Willey, C.D., Novak, J. Can the crosstalk between PDGF receptor and Axl in mesangial cells represent a possible therapeutic target in IgA nephropathy? J. Am. Soc. Nephrol. 31, 564
  • 2020 Developing molecular-specific biomarker assays for IgA nephropathy and IgA vasculitis with nephritis URL: https://journals.lww.com/jasn/citation/2020/10001/developing_molecular_specific_biomarker_assays_for.2002.aspx Hansen, A.L., Craine, E.P., Hargett, A.A., Hall, S., Rizk, D.V., Julian, B.A., Novak, J., Renfrow, M.B. Developing molecular-specific biomarker assays for IgA nephropathy and IgA vasculitis with nephritis. J. Am. Soc. Nephrol. 31, 562
  • 2020 Functional studies of IgG autoantibodies in IgA nephropathy URL: https://journals.lww.com/jasn/citation/2020/10001/functional_studies_of_igg_autoantibodies_in_iga.2006.aspx Knoppova, B., Hansen, A.L., Moldoveanu, Z., Hall, S., Huang, Z.Q., Novak, L., Julian, B.A., Renfrow, M.B., Novak, J., Green, T.J. Functional studies of IgG autoantibodies in IgA nephropathy. J. Am. Soc. Nephrol. 31, 563
  • 2020 Identification of proteins associated with IgA1-containing circulating immune complexes in patients with IgA nephropathy URL: https://journals.lww.com/jasn/citation/2020/10001/identification_of_proteins_associated_with.1999.aspx Bunten, M., Holloway, A., Hargett, A.A., Hall, S., Huang, Z.Q., Maillard, N., Julian, B.A., Novak, J., Renfrow, M.B. Identification of proteins associated with IgA1-containing circulating immune complexes in patients with IgA nephropathy. J. Am. Soc. Nephrol. 31, 562
  • 2020 Mass Spectrometric Analysis of IgA1 O-Glycoforms Reveals the Basis of IgA1 Galactose Deficiency Detected by Quantitative Lectin ELISA URL: https://journals.lww.com/jasn/citation/2020/10001/mass_spectrometric_analysis_of_iga1_o_glycoforms.2003.aspx Craine, E.P., Ueda, H., Ueda, Y., Reily, C., Moldoveanu, Z., Hall, S., Yokoo, T., Rizk, D.V., Kiryluk, K., Gharavi, A.G., Julian, B.A., Novak, J., Renfrow, M.B. Mass spectrometric analysis of IgA1 O-glycoforms reveals the basis of IgA1 galactose deficiency detected by quantitative lectin ELISA. J. Am. Soc. Nephrol. 31, 563
  • 2020 Single-cell transcriptomic profiling reveals aberrant signaling responses to Tfh cytokines in IgA1-secreting cells from IgA nephropathy patients URL: https://journals.lww.com/jasn/citation/2020/10001/single_cell_transcriptomic_profiling_reveals.2033.aspx Reily, C., Nakazawa, S., Kamata, M., Crossman, D., Rizk, D.V., Julian, B.A., Novak, J. Single-cell transcriptomic profiling reveals aberrant signaling responses to Tfh cytokines in IgA1-secreting cells from IgA nephropathy patients. J. Am. Soc. Nephrol. 31, 571
  • 2020 Characterization of a recombinant IgG autoantibody specific for galactose-deficient IgA1 in IgA nephropathy ? Knoppova, B., Hansen, A.L., Moldoveanu, Z., Hall, S., Huang, Z.Q., Novak, L., Julian, B.A., Renfrow, M.B., Novak, J., Green, T.J. Characterization of a recombinant IgG autoantibody specific for galactose-deficient IgA1 in IgA nephropathy. Glycobiology. 30 (12), 1068
  • 2019 The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy PMID: 30941137  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+30941137+ URL: https://pubmed.ncbi.nlm.nih.gov/30941137/ Rizk, D.V., Maillard, N., Julian, B.A., Knoppova, B., Green, T.J., Novak, J., Wyatt, R.J. The emerging role of complement proteins as a target for therapy of IgA nephropathy. Front. Immunol. 10, article 504. doi: 10.3389/fimmu.2019.00504 PMCID: PMC6433978
  • 2019 IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2 PMID: 30759204 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+30759204 URL: https://pubmed.ncbi.nlm.nih.gov/30759204/ Stewart, T.S., Takahashi, K., Whitaker, R.H., Raska, M., Placzek, W.J., Novak, J.,* Renfrow, M.B.* (*co-corresponding co-senior authors) IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2. Glycobiology. 29(7), 543-556. doi: 10.1093/glycob/cwz007 PMCID: PMC6583770.
  • 2019 Glycosylation in health and disease PMID: 30858582  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+30858582+ URL: https://pubmed.ncbi.nlm.nih.gov/30858582/ Reily, C.,# Stewart, T.,# Renfrow, M.B.,* Novak, J.* Glycosylation in health and disease. (#co-first authors; *co-senior, co-corresponding authors) Invited review. Nat. Rev. Nephrol. 15, 346-366. doi.org/10.1038/s41581-019-0129-4  PMCID: PMC6590709
  • 2019 Glomerular Immunodeposits of Patients with IgA Nephropathy Are Enriched for IgG Autoantibodies Specific for Galactose-Deficient IgA1 PMID: 31444275  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+31444275+ URL: https://pubmed.ncbi.nlm.nih.gov/31444275/ Rizk, D.V., Saha, M.K., Hall, S., Novak, L., Brown, R., Huang, Z.Q., Fatima, H., Julian, B.A., Novak, J. Glomerular immunodeposits of patients with IgA nephropathy are enriched for IgG autoantibodies specific for galactose-deficient IgA1. J. Am. Soc. Nephrol. 30, 2017–2026. PMCID: PMC6779349
  • 2019 Autoantibodies Specific for Galactose-Deficient IgA1 in IgA Vasculitis With Nephritis PMID: 31844808 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+31844808 URL: https://pubmed.ncbi.nlm.nih.gov/31844808/ Suzuki, H., Moldoveanu, Z., Julian, B.A., Wyatt, R.J., Novak, J. Autoantibodies specific for galactose-deficient IgA1 in IgA vasculitis with nephritis. Kidney Int. Rep. 4(12), 1717-1724. PMCID: PMC6895670
  • UAB 2019 – School of Medicine report included story on our JASN paper concerning IgG autoantibodies in IgAN biopsy specimens
  • January 22, 2019 – Proteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy
  • 2018 Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy PMID: 29324897 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+29324897 URL: https://pubmed.ncbi.nlm.nih.gov/29324897/ Placzek, W.J., Yanagawa, H., Makita, Y., Renfrow, M.B., Julian, B.A., Rizk, D.V., Suzuki, Y., Novak, J., Suzuki, H. Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy. PLoS ONE. 13(1): e0190967
  • 2018 Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients PMID: 30091383 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+30091383 URL: https://pubmed.ncbi.nlm.nih.gov/30091383/ Reily, C., Rizk, D.V., Julian, B.A., Novak, J. Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients. BioTechniques. 65(2), 71-77. doi: 10.2144/btn-2018-0042 
  • 2018 Aberrant Glycosylation of the IgA1 Molecule in IgA Nephropathy PMID: 30177018 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+30177018 URL: https://pubmed.ncbi.nlm.nih.gov/30177018/ Novak, J., Barratt, J., Julian, B.A., Renfrow, M.B. Aberrant glycosylation of the IgA1 molecule in IgA nephropathy. Invited review. Semin. Nephrol. 38(5), 461-476. DOI: https://doi.org/10.1016/j.semnephrol.2018.05.016
  • October 2018 – IGAN Foundation UAB progress report 2018
  • October 2018 –IGAN Foundation UAB publications 2018
  • 2017 What insights can proteomics give us into IgA nephropathy (Berger’s disease)? PMID: 28535694 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+28535694 URL: https://pubmed.ncbi.nlm.nih.gov/28535694/ Renfrow, M.B., Novak, J. What insights can proteomics give us into IgA nephropathy (Berger’s disease)? Invited review. Expert Rev. Proteomics. 14, 645-647
  • 2017 Prognostic Value of Serum Biomarkers of Autoimmunity for Recurrence of IgA Nephropathy after Kidney Transplantation PMID: 28255003  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+28255003+ URL: https://pubmed.ncbi.nlm.nih.gov/28255003/ Berthoux, F., Suzuki, H., Mohey, H., Maillard, N., Mariat, C., Novak, J., Julian, B.A. Serum biomarkers of autoimmunity predict recurrence of IgA nephropathy after kidney transplantation. J. Am. Soc. Nephrol. 28, 1943-1950
  • 2017 Noninvasive diagnosis of chronic kidney diseases using urinary proteome analysis PMID: 27984204 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+27984204 URL: https://pubmed.ncbi.nlm.nih.gov/27984204/ Siwy, J., Zürbig, P., Argiles, A., Beige, J., Haubitz, M., Jankowski, J., Julian, B.A., Linde, P.G., Marx, D., Mischak, H., Mullen, W., Novak, J., Ortiz, A., Persson, F., Pontillo, C., Rossing, P., Ruprecht, H., Schanstra, J.P., Vlahou, A., Vanholder, R. Non-invasive diagnosis of chronic kidney diseases using urinary proteome analysis. Nephol. Dial. Transplant. 32, 2079-2089
  • 2017 Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy URL: https://www.kireports.org/article/S2468-0249(17)30300-5/fulltext Yamada, K., Huang, Z.-Q., Raska, M., Reily, C.R., Aderson, J., Suzuki, H., Ueda, H., Moldoveanu, Z., Kiryluk, K., Suzuki, Y., Wyatt, R.J., Tomino, Y., Gharavi, A.G., Weinmann, A., Julian, B.A., Willey, C.D., Novak, J. Inhibition of STAT3 signaling reduces IgA1 autoantigen production in IgA nephropathy. Kidney Int. Rep. 2, 1194–1207
  • 2016 Toward Noninvasive Diagnosis of IgA Nephropathy: A Pilot Urinary Metabolomic and Proteomic Study PMID: 27799660  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+27799660+ URL: https://pubmed.ncbi.nlm.nih.gov/27799660/ Neprasova, M., Maixnerová, D., Novak, J., Reily, C., Julian, B.A., Boron, J., Novotny, P., Suchanek, M., Tesar, V., Petr Kacer, P. Toward non-invasive diagnosis of IgA nephropathy: a pilot urinary metabolomic and proteomic study. Dis. Markers. Article ID 3650909. PMCID: PMC5075301
  • 2016 The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy PMID: 27148252  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+27148252+ URL: https://pubmed.ncbi.nlm.nih.gov/27148252/ Knoppova, B.,# Reily, C.,# Maillard, N.,# Rizk, D.V., Moldoveanu, M., Mestecky, J., Raska, M., Renfrow, M.B., Julian, B.A., Novak, J.  (#co-first authors) The origin and activities of IgA1-containing immune complexes in IgA nephropathy.  (Invited review for Special Topic: Molecular Mechanisms of Immune Complex Pathophysiology.) Front. Immunol. 7:117. doi: 10.3389/fimmu.2016.00117 PMCID: PMC4828451
  • 2016 Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy PMID: 26966014  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+26966014+ URL: https://pubmed.ncbi.nlm.nih.gov/26966014/ Huang, Z.Q., Raska, M., Stewart, T., Reily, C., King, R.G., Crossman, D.K., Crowley, M.R., Hargett, A., Zhang, Z., Suzuki, H., Hall, S., Wyatt, R.J., Julian, B.A., Renfrow, M.B., Gharavi, A.G., Novak, J. Somatic mutations modulate autoantibodies against galactose-deficient IgA1 in IgA nephropathy. J. Am. Soc. Nephrol. 27, 3278-3284. PMCID: PMC5084875
  • 2016 Markers for the progression of IgA nephropathy PMID: 27142988 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+27142988 URL: https://pubmed.ncbi.nlm.nih.gov/27142988/ Maixnerova, D.,# Reily, C.,# Bian, Q.,# Michaela Neprasova, M., Novak, J., Tesar, V. (#co-first authors) Markers for the progression of IgA nephropathy. J. Nephrol. 29, 535-541
  • 2016 IgA nephropathy PMID: 27189177 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+27189177 URL: https://pubmed.ncbi.nlm.nih.gov/27189177/ Lai, K.N., Tang, S.C.W., Schena, F.P., Novak, J., Tomino, Y., Foggo, A.B., Glassock, R.J. IgA nephropathy. Nat. Rev. Dis. Primers 2, Article number (16001). doi:10.1038/nrdp.2016.1 
  • 2016 Galactose-Deficient IgA1 as a Candidate Urinary Polypeptide Marker of IgA Nephropathy? PMID: 27647947  NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+27647947+ URL: https://pubmed.ncbi.nlm.nih.gov/27647947/ Suzuki, H., Allegri, L., Suzuki, Y., Hall, S., Moldoveanu, Z., Wyatt, R.J., Novak, J., Julian, B.A. Galactose-deficient IgA1 as a candidate urinary polypeptide marker of IgA nephropathy? Dis. Markers. 2016, Article ID 7806438. PMCID: PMC5018335
  • 2016 Aberrant Glycosylation of the IgA1 Molecule in IgA Nephropathy PMID: 30177018 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+30177018 URL: https://pubmed.ncbi.nlm.nih.gov/30177018/ Novak, J., Takahashi, K., Suzuki, H., Reily, C., Stewart, T., Ueda, H., Yamada, K., Moldoveanu, Z., M. Hastings, C., Wyatt, R.J., Mestecky, J., Raska, M., Julian, B.A., Renfrow, M.B. Heterogeneity of Aberrant O-glycosylation of IgA1 in IgA Nephropathy. In: Pathogenesis and Treatment in IgA Nephropathy, Tomino, Y., Ed, Springer, Tokyo, Japan, pp. 53-68
  • April 12, 2016 – The Origin and Activities of IgA1- Containing immune Complexes in igA Nephropathy
  • March 21, 2016 –Markers for the progression of IgA nephropathy
  • February 11, 2016 – IgA nephropathy
  • February 4, 2016 – Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy
  • 2016 – Heterogeneity of Aberrant O-Glycosylation of IgA1 in IgA Nephropathy
  • 2015 New Insights into the Pathogenesis of IgA Nephropathy PMID: 26568951 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+26568951 URL: https://pubmed.ncbi.nlm.nih.gov/26568951/ Novak, J., Rizk, D.V., Takahashi, K., Zhang, X.W., Bian, Q., Ueda, H., Ueda, Y., Reily, C., Lai, L.Y., Hao, C.M., Novak, L., Huang, Z.Q., Renfrow, M.B., Suzuki, H., Julian, B.A. New insights into the pathogenesis of IgA nephropathy. Kidney Dis. 1, 8-18. PMCID: PMC4640461
  • 2015 N-acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy PMID: 25281698 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+25281698 URL: https://pubmed.ncbi.nlm.nih.gov/25281698/ Stuchlova Horynova, M., Vrablikova, A., Stewart, T.J., Takahashi, K., Czernekova, L., Yamada, K., Suzuki, H., Julian, B.A., Renfrow, M.B., Novak, J.,# Raska, M.# N-acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy. Nephrol. Dial. Transplant. 30, 234-238. (#co-senior/co-corresponding authors) 
  • 2015 Current Understanding of the Role of Complement in IgA Nephropathy PMID: 25694468 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+25694468 URL: https://pubmed.ncbi.nlm.nih.gov/25694468/ Maillard, N., Wyatt, R.J., Julian, B.A., Kiryluk, K., Gharavi, A., Fremeaux-Bacchi, V., Novak, J. Current understanding of the role of complement in IgA nephropathy. J. Am. Soc. Nephrol. Invited review. 26, 1503-1512
  • 2015 IgA Nephropathy and Related Diseases. In: Mucosal Immunology, 4th edition URL: https://www.sciencedirect.com/science/article/abs/pii/B9780124158474001051 Novak, J., Raska, M., Mestecky, J., Julian, B.A. IgA Nephropathy and Related Diseases. In: Mucosal Immunology, 4th edition. Jiri Mestecky, Warren Strober, Michael W. Russell, Brian Kelsall, Hilde Cheroutre, Bart Lambrecht, Editors. Academic Press-Elsevier, Boston, USA, pp. 2023-2038
  • May 1, 2015 –New Insights into the Pathogenesis of IgA Nephropathy
  • 2015 – IgA Nephropathy and Related Diseases
  • 2015 – Current Understanding of the Role of Complement in IgA Nephropathy
  • 2014 The genetics and immunobiology of IgA nephropathy PMID: 24892706 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+24892706 URL: https://pubmed.ncbi.nlm.nih.gov/24892706/ Kiryluk, K., Novak, J. The genetics and immunobiology of IgA nephropathy. J. Clin. Invest. 124(6), 2325-2332. PMCID: PMC4089454
  • 2014 Immune profile of IgA-dominant diffuse proliferative glomerulonephritis PMID: 25878780 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+25878780 URL: https://pubmed.ncbi.nlm.nih.gov/25878780/ Wallace, E., Maillard, N., Ueda, H., Hall, S., Fatima, H., Novak, J., Julian, B.A. Immune profile of IgA-dominant diffuse proliferative glomerulonephritis. Clin. Kidney J. 7, 479-483
  • October 12, 2014 –Discovery of new risk loci for IgA Nephropathy implicates genes involved in immunity against intestinal pathogens. Kiryluk, K., Li, Y., Scolari, F., Sanna-Cherchi, S., Choi, M., Verbitsky, M., …… Gharavi, G. A. (2014). Discovery of new risk loci for iga nephropathy implicates genes involved in immunity against intestinal pathogens. Nature Genetics, 46(11), 1187-1199
  • October 3, 2014 –N-Acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy
  • July 23, 2014 – Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease.Reily, C., Ueda, H., Huang, Z.,Mestecky, J., Julian, A. B., Willey, D. C., & Novak, J. (2014). Cellular signaling and production of galactose-deficient iga1 in iga nephropathy, an autoimmune disease. Journal of Immunology Research, 1-10
  • July 1, 2014 – The combined role of galactose-deficient IgA1and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy. Schmitt R, Ståhl AL, Olin AI, Kristoffersson AC, Rebetz J, Novak J, Lindahl G, Karpman D.J Immunol. 2014 Jul 1;193(1):317-26. doi: 10
  • 2014 Enzymatic sialylation of IgA1 O-glycans: implications for studies of IgA nephropathy PMID: 24918438 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+24918438 URL: https://pubmed.ncbi.nlm.nih.gov/24918438/ Takahashi, K., Raska, M., Stuchlova Horynova, M., Hall, S. Poulsen, K., Kilian, M., Hiki, Y., Yuzawa, Y., Moldoveanu, Z., Julian, B.A., Renfrow, M.B., Novak, J. Enzymatic sialylation of IgA1 O-glycans: Implications for studies of IgA nephropathy. PLoS ONE 9(6), e99026. PMCID: PMC4053367
  • 2014 Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens PMID: 25305756 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+25305756 URL: https://pubmed.ncbi.nlm.nih.gov/25305756/ Kiryluk, K., Li, Y., Scolari, F., Sanna-Cherchi, S., Choi, M., Verbitsky, M., Fasel, D., Lata, S., Prakash, S., Shapiro, S., Fischman, C., Snyder, H.J., Appel, G., Izzi, C., Viola, B.F., Dallera, N., Del Vecchio, L., Barlassina, C., Salvi, E., Bertinetto, F.E., Amoroso, A., Savoldi, S., Rocchietti, M., Amore, A., Peruzzi, L., Coppo, R., Salvadori, M., Ravani, P., Magistroni, R., Ghiggeri, G.M., Caridi, G., Bodria, M., Lugani, F., Allegri, L., Delsante, M., Maiorana, M., Magnano, A., Frasca, G., Boer, E., Boscutti, G., Ponticelli, C., Mignani, R., Marcantoni, C., Di Landro, D., Santoro, D., Pani, A., Polci, R., Feriozzi, S., Chicca, S., Galliani, M., Gigante, M., Gesualdo, L., Zamboli, P., Battaglia, G.G., Garozzo, M., Maixnerová, D., Tesar, V., Eitner, F., Rauen, T., Floege, J., Kovacs, T., Nagy, J., Mucha, K., Pączek, L., Zaniew, M., Mizerska-Wasiak, M., Roszkowska-Blaim, M., Pawlaczyk, K., Gale, D., Barratt, J., Thibaudin, L., Berthoux, F., Canaud, G., Boland, A., Metzger, M., Panzer, U., Suzuki, H., Goto, S., Narita, I., Caliskan, Y., Xie, J., Hou, P., Chen, N., Zhang, H., Wyatt, R.J., Novak, J., Julian, B.A., Feehally, J., Stengel, B., Cusi, D., Lifton, R.P., Gharavi, A.G. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat. Genet. 46, 1187-1196. PMCID: PMC4213311
  • 2014 Development of Animal Models of Human IgA Nephropathy PMID: 25722731 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+25722731 URL: https://pubmed.ncbi.nlm.nih.gov/25722731/ Suzuki, H., Suzuki, Y., Novak, J., Tomino, Y. Development of animal models of human IgA nephropathy. Drug Discov. Today Dis. Models. Invited Review. 11, 5-11
  • 2014 Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes PMID: 24398680 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+24398680 URL: https://pubmed.ncbi.nlm.nih.gov/24398680/ Suzuki, H., Raska, M., Yamada, K., Moldoveanu, Z., Julian, B.A., Wyatt, R.J., Tomino, Y., Gharavi, A.G., Novak, J. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J. Biol. Chem. 289, 5330-5339. PMCID: PMC3931088
  • 2014 Cellular signaling and production of galactose-deficient IgA1 in IgA nephropathy, an autoimmune disease PMID: 25152896 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+25152896 URL: https://pubmed.ncbi.nlm.nih.gov/25152896/ Reily, C.R., Ueda, H., Huang, Z.-Q., Mestecky, J., Julian, B.A., Willey, C.D., Novak, J.  Cellular signaling and production of galactose-deficient IgA1 in IgA nephropathy, an autoimmune disease. J. Immunol. Res. 2014, article ID 197548
  • 2014 .4049/jimmunol.1302249. Epub 2014 May 21.
  • June 2014 – The genetics and immunobiology of IgA nephropathy. Kiryluk K, Novak J.J Clin Invest. 2014 Jun;124(6):2325-32. doi: 10.1172/JCI74475. Epub 2014 Jun 2. Review.
  • June 2014 – Enzymatic Sialylation of IgA1 O-Glycans: Implications for Studies of IgA Nephropathy. Takahashi K, Raska M, Stuchlova Horynova M, Hall SD, Poulsen K, Kilian M, Hiki Y, Yuzawa Y, Moldoveanu Z, Julian BA, Renfrow MB, Novak J. PLoS One. 2014 Jun 11;9(2):e99026. doi: 10.1371/journal.pone.0099026. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e113577.
  • February, 2014 – Cytokines Alter IgA1 O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes*. Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J. J Biol Chem. 2014 Feb 21;289(8):5330-9. doi: 10.1074/jbc.M113.512277. Epub 2014 Jan 7.
  • 2014 – Immune profile of IgA-dominant diffuse proliferative glomerulonephritis. Wallace E, Maillard N, Ueda H, Hall S, Fatima H, Novak J, Julian BA.Clin Kidney J. 2014 Oct;7(5):479-83. doi: 10.1093/ckj/sfu090.
  • 2014 – Development of animal models of human IgA nephropathy. Suzuki H, Suzuki Y, Novak J, Tomino Y. Drug Discov Today Dis Models. 2014 Spring;11:5-11.
  • 2013 Pathogenesis of IgA Nephropathy PMID: 23511518 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID:%2023511518 URL: https://pubmed.ncbi.nlm.nih.gov/23511518/ Novak, J. Renfrow, M.B., Gharavi, A.G., Julian, B.A. Pathogenesis of IgA Nephropathy. Invited review. Current Opin. Nephrol. Hypertens. 22, 287-294
  • 2013 IgA nephropathy: molecular mechanisms of the disease PMID: 23092188 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+23092188 URL: https://pubmed.ncbi.nlm.nih.gov/23092188/ Mestecky, J., Raska, M., Julian, B.A., Gharavi, A.G., Renfrow, M.B., Moldoveanu, Z., Novak, L., Matousovic, K., Novak, J. IgA nephropathy: Molecular mechanisms of the disease. Annu. Rev. Pathol. Mech. Dis. 8, 217-240
  • 2013 Biomarkers in IgA nephropathy: relationship to pathogenetic hits PMID: 24175678 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+24175678 URL: https://pubmed.ncbi.nlm.nih.gov/24175678/ Hastings, M.C., Moldoveanu, Z., Suzuki, H., Berthoux, F., Julian, B.A., Sanders, J.T., Renfrow, M. B., Novak, J., Wyatt, R.J. Biomarkers in IgA nephropathy: Relationship to pathogenetic hits. Expert Opin. Med. Diagn. 7, 615-627
  • 2013 Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma   PMID: 22864623 NIH: https://www.ncbi.nlm.nih.gov/search/all/?term=PMID%3A+22864623 URL: https://pubmed.ncbi.nlm.nih.gov/22864623/ Stuchlova Horynova, M., Raska, M., Clausen, H., Novak, J. Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma. Cell. Mol. Life Sci. 70, 829–839
  • September 23, 2011 –JASN The Pathophysiology of IgA Nephropathy. Hitoshi, S., Kiryluk, K., Novak, J., Moldoveanu, Z., Herr B. A., Renfrow, B. M., …. Julian, A. B. (2011). The pathophysiology of iga nephropathy. Journal of the American Society of Nephrology, 22, 1795-1803.
  • September 8, 2011 – JASN Current Therapy for IgA Nephropathy. Floege, J., & Eitner F. (2011). Current therapy for iga nephropathy. Journal of the American Society of Nephrology, 22, 1785-1794
    September 1, 2011 – IgA Nephropathy and Anti-B-Cell Therapy PowerPoint. Dr Adrian Liew
  • June 10, 2010 – UAB Search for IgA Nephropathy Screening Tool Intensifies. (2010). UAB search for iga nephropathy screening tool intensifies. UAB Synopsis, 29(26).
  • Tufts Leadership Team – Dr. Plaut
  • Tufts Success Stories – Using Enzymes to Reverse Kidney Disease